KIC60049.1 protein (Microbacterium hominis) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Cooccurrence

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[Homology]

Score

KIC60049.1

Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (398 aa)

Predicted Functional Partners:

KIC60050.1

0.980

KIC58256.1

0.928

KIC60073.1

0.916

KIC60265.1

0.912

KIC58278.1

0.890

KIC60227.1

0.887

KIC58069.1

0.877

phoU

0.870

KIC59363.1

0.869

KIC60285.1

0.860

Your Current Organism:

Microbacterium hominis

NCBI taxonomy Id: 162426
Other names: CIP 105731, DSM 12509, IFO 15708, JCM 12413, LCDC 84-209, M. hominis, NBRC 15708, VKM Ac-2081

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KIC58069.1	KIC60049.1	RM52_08165	RM52_01160	Fis family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.877
KIC58256.1	KIC60049.1	RM52_05880	RM52_01160	Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.928
KIC58278.1	KIC60049.1	RM52_06000	RM52_01160	Chemotaxis protein CheY; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.890
KIC59363.1	KIC60049.1	RM52_03955	RM52_01160	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.869
KIC60049.1	KIC58069.1	RM52_01160	RM52_08165	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Fis family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.877
KIC60049.1	KIC58256.1	RM52_01160	RM52_05880	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.928
KIC60049.1	KIC58278.1	RM52_01160	RM52_06000	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Chemotaxis protein CheY; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.890
KIC60049.1	KIC59363.1	RM52_01160	RM52_03955	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.869
KIC60049.1	KIC60050.1	RM52_01160	RM52_01165	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	XRE family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.980
KIC60049.1	KIC60073.1	RM52_01160	RM52_01295	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.916
KIC60049.1	KIC60227.1	RM52_01160	RM52_02200	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.887
KIC60049.1	KIC60265.1	RM52_01160	RM52_02455	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.912
KIC60049.1	KIC60285.1	RM52_01160	RM52_00195	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.860
KIC60049.1	phoU	RM52_01160	RM52_01155	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	PhoU family transcriptional regulator; Plays a role in the regulation of phosphate uptake.	0.870
KIC60050.1	KIC60049.1	RM52_01165	RM52_01160	XRE family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.980
KIC60050.1	phoU	RM52_01165	RM52_01155	XRE family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	PhoU family transcriptional regulator; Plays a role in the regulation of phosphate uptake.	0.647
KIC60073.1	KIC60049.1	RM52_01295	RM52_01160	Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.916
KIC60227.1	KIC60049.1	RM52_02200	RM52_01160	Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.887
KIC60265.1	KIC60049.1	RM52_02455	RM52_01160	Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.912
KIC60285.1	KIC60049.1	RM52_00195	RM52_01160	Response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.860

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Network Stats

number of nodes:

11

number of edges:

48

average node degree:

8.73

avg. local clustering coefficient:

0.915

expected number of edges:

13

PPI enrichment p-value:

3.57e-14

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007059

Chromosome segregation

9 of 76

2.24

6.67

3.63e-16

GO:0000819

Sister chromatid segregation

7 of 38

2.43

6.07

2.90e-13

GO:0000070

Mitotic sister chromatid segregation

6 of 34

2.41

5.21

2.64e-11

GO:0000280

Nuclear division

7 of 77

2.13

4.8

1.23e-11

GO:1903047

Mitotic cell cycle process

8 of 161

1.86

4.1

1.08e-11

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0035174

Histone serine kinase activity

2 of 2

3.17

1.98

0.00027

GO:0140657

ATP-dependent activity

6 of 456

1.29

1.39

4.80e-05

GO:0016887

ATP hydrolysis activity

4 of 242

1.39

1.15

0.0014

GO:0005524

ATP binding

8 of 1002

1.07

1.09

4.80e-05

GO:0003697

Single-stranded DNA binding

2 of 32

1.96

0.96

0.0145

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0044815

DNA packaging complex

5 of 55

2.13

3.44

5.40e-08

GO:0000793

Condensed chromosome

5 of 55

2.13

3.44

5.40e-08

GO:0000796

Condensin complex

3 of 3

3.17

3.42

6.25e-07

GO:0005694

Chromosome

9 of 341

1.59

3.09

4.01e-11

GO:0005876

Spindle microtubule

3 of 10

2.64

2.75

7.64e-06

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:14064

SUMOylation of DNA damage response and repair proteins, and Condensin complex

7 of 20

2.71

7.18

9.89e-15

CL:14065

Cohesin complex, and Condensin complex

5 of 11

2.82

5.15

2.12e-10

CL:14068

Cohesin complex

2 of 5

2.77

1.47

0.0021

CL:10128

Chromosome passenger complex, and Transposon, En/Spm-like

2 of 5

2.77

1.47

0.0021

CL:14089

Smc5-Smc6 complex

2 of 6

2.69

1.45

0.0023

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04111

Cell cycle - yeast

5 of 131

1.75

2.35

2.52e-06

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-3108214

SUMOylation of DNA damage response and repair proteins

4 of 18

2.51

3.44

2.66e-07

MAP-68877

Mitotic Prometaphase

5 of 53

2.14

3.3

1.31e-07

MAP-3108232

SUMO E3 ligases SUMOylate target proteins

5 of 87

1.93

2.81

5.68e-07

MAP-2514853

Condensation of Prometaphase Chromosomes

3 of 12

2.56

2.59

1.43e-05

MAP-69278

Cell Cycle, Mitotic

7 of 274

1.57

2.4

1.31e-07

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000793

Condensed chromosome

7 of 110

1.97

4.01

2.49e-10

GOCC:0005694

Chromosome

9 of 491

1.43

2.46

3.06e-10

GOCC:0000796

Condensin complex

2 of 2

3.17

1.91

0.00035

GOCC:0043232

Intracellular non-membrane-bounded organelle

11 of 1152

1.15

1.65

2.49e-10

GOCC:0030915

Smc5-Smc6 complex

2 of 5

2.77

1.62

0.0011

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0226

DNA condensation

2 of 2

3.17

1.78

0.00062

KW-0498

Mitosis

2 of 4

2.87

1.71

0.00078

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13476

AAA domain

4 of 4

3.17

4.4

9.43e-09

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036277

SMCs flexible hinge superfamily

3 of 3

3.17

2.65

1.57e-05

IPR003395

RecF/RecN/SMC, N-terminal

3 of 3

3.17

2.65

1.57e-05

IPR024704

Structural maintenance of chromosomes protein

2 of 2

3.17

1.42

0.0028

IPR010935

SMCs flexible hinge

2 of 2

3.17

1.42

0.0028

IPR030616

Aurora kinase-like

2 of 3

2.99

1.41

0.0028

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00968

SMC proteins Flexible Hinge Domain

2 of 2

3.17

1.69

0.00091

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