KJS00898.1 protein (Desulfobulbaceae bacterium BRHc16a)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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[Homology]

Score

KJS00898.1

Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (149 aa)

Predicted Functional Partners:

KJS00895.1

0.773

KJS00896.1

0.773

KJS00897.1

0.773

KJS00899.1

0.723

KJS00900.1

0.723

Your Current Organism:

Desulfobulbaceae bacterium BRHc16a

NCBI taxonomy Id: 1629713
Other names: D. bacterium BRH_c16a, Desulfobulbaceae bacterium BRH_c16a

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KJS00895.1	KJS00896.1	VR65_10850	VR65_10855	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.776
KJS00895.1	KJS00897.1	VR65_10850	VR65_10860	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.788
KJS00895.1	KJS00898.1	VR65_10850	VR65_10865	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.773
KJS00895.1	KJS00899.1	VR65_10850	VR65_10870	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.738
KJS00895.1	KJS00900.1	VR65_10850	VR65_10875	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.723
KJS00896.1	KJS00895.1	VR65_10855	VR65_10850	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.776
KJS00896.1	KJS00897.1	VR65_10855	VR65_10860	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.778
KJS00896.1	KJS00898.1	VR65_10855	VR65_10865	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.773
KJS00896.1	KJS00899.1	VR65_10855	VR65_10870	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.727
KJS00896.1	KJS00900.1	VR65_10855	VR65_10875	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.723
KJS00897.1	KJS00895.1	VR65_10860	VR65_10850	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.788
KJS00897.1	KJS00896.1	VR65_10860	VR65_10855	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.778
KJS00897.1	KJS00898.1	VR65_10860	VR65_10865	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.773
KJS00897.1	KJS00899.1	VR65_10860	VR65_10870	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.731
KJS00897.1	KJS00900.1	VR65_10860	VR65_10875	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.723
KJS00898.1	KJS00895.1	VR65_10865	VR65_10850	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.773
KJS00898.1	KJS00896.1	VR65_10865	VR65_10855	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.773
KJS00898.1	KJS00897.1	VR65_10865	VR65_10860	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.773
KJS00898.1	KJS00899.1	VR65_10865	VR65_10870	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.723
KJS00898.1	KJS00900.1	VR65_10865	VR65_10875	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.723

page 1 of 2

Network Stats

number of nodes:

8

number of edges:

20

average node degree:

5

avg. local clustering coefficient:

0.869

expected number of edges:

10

PPI enrichment p-value:

0.00518

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030276

Clathrin binding

4 of 16

2.32

2.98

5.31e-06

GO:0035615

Clathrin adaptor activity

2 of 7

2.38

0.92

0.0295

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005905

Clathrin-coated pit

4 of 8

2.62

3.8

3.09e-07

GO:0030131

Clathrin adaptor complex

4 of 9

2.57

3.78

3.09e-07

GO:0030125

Clathrin vesicle coat

4 of 12

2.44

3.65

3.77e-07

GO:0030122

AP-2 adaptor complex

2 of 3

2.75

1.96

0.00058

GO:0016020

Membrane

6 of 1434

0.54

0.33

0.0443

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5613

Clathrin binding, and AP-3 adaptor complex

4 of 22

2.18

2.67

1.41e-05

CL:5614

Clathrin binding

3 of 12

2.32

2.26

0.00012

CL:961

Cardiolipin acyl-chain remodeling, and The canonical retinoid cycle in rods (twilight vision)

2 of 6

2.44

1.39

0.0049

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04144

Endocytosis

4 of 122

1.44

1.29

0.0011

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-437239

Recycling pathway of L1

4 of 7

2.68

3.88

2.48e-07

MAP-8964038

LDL clearance

4 of 11

2.48

3.61

5.11e-07

MAP-8866427

VLDLR internalisation and degradation

4 of 11

2.48

3.61

5.11e-07

MAP-373760

L1CAM interactions

4 of 13

2.41

3.56

5.11e-07

MAP-8964043

Plasma lipoprotein clearance

4 of 16

2.32

3.41

7.24e-07

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0030131

Clathrin adaptor complex

4 of 7

2.68

3.89

2.44e-07

GOCC:0030125

Clathrin vesicle coat

4 of 11

2.48

3.61

5.04e-07

GOCC:0030122

AP-2 adaptor complex

2 of 3

2.75

1.88

0.00079

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0653

Protein transport

4 of 57

1.77

1.97

9.10e-05

KW-0813

Transport

5 of 181

1.36

1.49

9.10e-05

KW-0472

Membrane

6 of 1154

0.64

0.39

0.0389

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR002553

Clathrin/coatomer adaptor, adaptin-like, N-terminal

3 of 8

2.5

2.02

0.00040

IPR016342

AP-1/2/4 complex subunit beta

2 of 2

2.92

1.28

0.0082

IPR026739

AP complex subunit beta

2 of 3

2.75

1.25

0.0091

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