KJS44557.1 protein (Rhodospirillaceae bacterium BRHc57)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

KJS44557.1

Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (120 aa)

Predicted Functional Partners:

KJS44558.1

0.962

KJS38441.1

0.825

KJS44556.1

0.479

gmk

0.467

KJS38449.1

0.464

Your Current Organism:

Rhodospirillaceae bacterium BRHc57

NCBI taxonomy Id: 1629718
Other names: R. bacterium BRH_c57, Rhodospirillaceae bacterium BRH_c57

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KJS38441.1	KJS38449.1	VR70_10070	VR70_10075	DNA polymerase beta; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.934
KJS38441.1	KJS44557.1	VR70_10070	VR70_01615	DNA polymerase beta; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.825
KJS38449.1	KJS38441.1	VR70_10075	VR70_10070	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA polymerase beta; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.934
KJS38449.1	KJS44557.1	VR70_10075	VR70_01615	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.464
KJS38449.1	KJS44558.1	VR70_10075	VR70_01610	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Nucleotidyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.842
KJS44556.1	KJS44557.1	VR70_01605	VR70_01615	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.479
KJS44556.1	KJS44558.1	VR70_01605	VR70_01610	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Nucleotidyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.488
KJS44556.1	gmk	VR70_01605	VR70_01600	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.974
KJS44557.1	KJS38441.1	VR70_01615	VR70_10070	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	DNA polymerase beta; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.825
KJS44557.1	KJS38449.1	VR70_01615	VR70_10075	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.464
KJS44557.1	KJS44556.1	VR70_01615	VR70_01605	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.479
KJS44557.1	KJS44558.1	VR70_01615	VR70_01610	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Nucleotidyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.962
KJS44557.1	gmk	VR70_01615	VR70_01600	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.467
KJS44558.1	KJS38449.1	VR70_01610	VR70_10075	Nucleotidyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.842
KJS44558.1	KJS44556.1	VR70_01610	VR70_01605	Nucleotidyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.488
KJS44558.1	KJS44557.1	VR70_01610	VR70_01615	Nucleotidyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.962
KJS44558.1	gmk	VR70_01610	VR70_01600	Nucleotidyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	0.471
gmk	KJS44556.1	VR70_01600	VR70_01605	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.974
gmk	KJS44557.1	VR70_01600	VR70_01615	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.467
gmk	KJS44558.1	VR70_01600	VR70_01610	Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.	Nucleotidyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.471

Network Stats

number of nodes:

5

number of edges:

8

average node degree:

3.2

avg. local clustering coefficient:

0.667

expected number of edges:

4

PPI enrichment p-value:

0.0502

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042128

Nitrate assimilation

3 of 17

2.47

1.67

0.00079

GO:0034975

Protein folding in endoplasmic reticulum

2 of 8

2.63

1.04

0.0130

GO:0006790

Sulfur compound metabolic process

4 of 279

1.38

0.84

0.0130

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043546

Molybdopterin cofactor binding

7 of 10

3.07

8.55

9.87e-17

GO:0030151

Molybdenum ion binding

7 of 20

2.77

7.56

2.25e-15

GO:0016670

Oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor

6 of 12

2.93

6.87

1.17e-13

GO:0008482

Sulfite oxidase activity

4 of 4

3.23

4.83

1.56e-09

GO:0020037

Heme binding

7 of 162

1.86

3.63

6.79e-10

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005758

Mitochondrial intermembrane space

4 of 75

1.96

1.95

9.88e-05

GO:0031967

Organelle envelope

5 of 785

1.03

0.64

0.0172

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:21707

Sulfide oxidation to sulfate

4 of 12

2.75

3.45

3.79e-07

CL:21208

Nitrate reductase (NADPH) activity

3 of 5

3.01

2.84

6.80e-06

CL:13456

Mixed, incl. Protein disulfide isomerase activity, and Amino-acid transport

3 of 23

2.34

2.03

0.00014

CL:21719

Sulfide oxidation to sulfate

2 of 6

2.75

1.54

0.0016

CL:21708

Sulfide oxidation to sulfate

2 of 6

2.75

1.54

0.0016

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00920

Sulfur metabolism

4 of 70

1.99

2.36

1.16e-05

map00910

Nitrogen metabolism

3 of 92

1.74

1.34

0.0016

map04141

Protein processing in endoplasmic reticulum

4 of 334

1.31

1.07

0.0017

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1614517

Sulfide oxidation to sulfate

4 of 13

2.72

3.64

1.57e-07

MAP-1614558

Degradation of cysteine and homocysteine

4 of 28

2.38

3.06

1.18e-06

MAP-1614635

Sulfur amino acid metabolism

4 of 50

2.13

2.56

6.87e-06

MAP-264876

Insulin processing

2 of 23

2.17

0.88

0.0237

MAP-71291

Metabolism of amino acids and derivatives

4 of 518

1.12

0.6

0.0346

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0274

FAD

5 of 106

1.9

2.71

8.76e-07

KW-0534

Nitrate assimilation

2 of 6

2.75

1.69

0.00084

KW-0500

Molybdenum

2 of 6

2.75

1.69

0.00084

KW-1015

Disulfide bond

2 of 49

1.84

0.85

0.0226

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF03404

Mo-co oxidoreductase dimerisation domain

7 of 8

3.17

8.84

3.84e-17

PF00174

Oxidoreductase molybdopterin binding domain

7 of 8

3.17

8.84

3.84e-17

PF00970

Oxidoreductase FAD-binding domain

3 of 13

2.59

2.21

7.92e-05

PF00175

Oxidoreductase NAD-binding domain

3 of 26

2.29

1.8

0.00039

PF04137

Endoplasmic Reticulum Oxidoreductin 1 (ERO1)

2 of 2

3.23

1.64

0.0011

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036374

Oxidoreductase, molybdopterin-binding domain superfamily

7 of 8

3.17

8.62

1.03e-16

IPR008335

Eukaryotic molybdopterin oxidoreductase

7 of 8

3.17

8.62

1.03e-16

IPR000572

Oxidoreductase, molybdopterin-binding domain

7 of 8

3.17

8.62

1.03e-16

IPR005066

Moybdenum cofactor oxidoreductase, dimerisation

6 of 7

3.16

7.36

2.56e-14

IPR014756

Immunoglobulin E-set

7 of 39

2.48

6.26

1.71e-13

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01117

Cytochrome b5-like Heme/Steroid binding domain

3 of 41

2.09

1.53

0.0011

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