KJS44361.1 protein (Rhodospirillaceae bacterium BRHc57)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

KJS44361.1

Response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (145 aa)

Predicted Functional Partners:

KJS44757.1

0.974

KJS40070.1

0.974

KJS38012.1

0.964

KJS39393.1

0.963

KJS34179.1

0.957

KJS43033.1

0.944

KJS35754.1

0.943

KJS41965.1

0.940

KJS43696.1

0.933

KJS34217.1

0.931

Your Current Organism:

Rhodospirillaceae bacterium BRHc57

NCBI taxonomy Id: 1629718
Other names: R. bacterium BRH_c57, Rhodospirillaceae bacterium BRH_c57

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KJS34179.1	KJS34217.1	VR70_18410	VR70_18350	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
KJS34179.1	KJS35754.1	VR70_18410	VR70_15205	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.997
KJS34179.1	KJS38012.1	VR70_18410	VR70_11255	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
KJS34179.1	KJS39393.1	VR70_18410	VR70_08125	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.998
KJS34179.1	KJS40070.1	VR70_18410	VR70_06780	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.998
KJS34179.1	KJS41965.1	VR70_18410	VR70_04525	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
KJS34179.1	KJS43033.1	VR70_18410	VR70_02985	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.997
KJS34179.1	KJS43696.1	VR70_18410	VR70_02305	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
KJS34179.1	KJS44361.1	VR70_18410	VR70_01700	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.957
KJS34179.1	KJS44757.1	VR70_18410	VR70_01475	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
KJS34217.1	KJS34179.1	VR70_18350	VR70_18410	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
KJS34217.1	KJS35754.1	VR70_18350	VR70_15205	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.969
KJS34217.1	KJS38012.1	VR70_18350	VR70_11255	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.960
KJS34217.1	KJS39393.1	VR70_18350	VR70_08125	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.960
KJS34217.1	KJS40070.1	VR70_18350	VR70_06780	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.967
KJS34217.1	KJS41965.1	VR70_18350	VR70_04525	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.997
KJS34217.1	KJS43033.1	VR70_18350	VR70_02985	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.968
KJS34217.1	KJS43696.1	VR70_18350	VR70_02305	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
KJS34217.1	KJS44361.1	VR70_18350	VR70_01700	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.931
KJS34217.1	KJS44757.1	VR70_18350	VR70_01475	Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.960

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

36

average node degree:

6.55

avg. local clustering coefficient:

0.767

expected number of edges:

13

PPI enrichment p-value:

1.28e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006007

Glucose catabolic process

2 of 2

2.62

1.28

0.0046

GO:0006351

Transcription, DNA-templated

3 of 34

1.57

0.95

0.0099

GO:0016070

RNA metabolic process

5 of 144

1.16

0.93

0.0022

GO:0006096

Glycolytic process

2 of 10

1.92

0.8

0.0307

GO:0006139

Nucleobase-containing compound metabolic process

9 of 508

0.87

0.79

0.00014

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003899

DNA-directed 5-3 RNA polymerase activity

3 of 9

2.14

1.48

0.0015

GO:0046537

2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity

2 of 2

2.62

1.25

0.0052

GO:0030145

Manganese ion binding

2 of 6

2.14

1.03

0.0120

GO:0140098

Catalytic activity, acting on RNA

4 of 90

1.27

0.9

0.0054

GO:0004518

Nuclease activity

3 of 59

1.33

0.73

0.0237

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000428

DNA-directed RNA polymerase complex

3 of 11

2.06

1.7

0.00045

GO:0005634

Nucleus

2 of 22

1.58

0.79

0.0246

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:344

RNA polymerase

3 of 5

2.4

1.74

0.00056

CL:1660

RNA recognition motif, and Beta-Casp domain

3 of 5

2.4

1.74

0.00056

CL:1578

Mixed, incl. Oxidative phosphorylation, and RNA recognition motif

5 of 81

1.41

1.28

0.00056

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03020

RNA polymerase

3 of 5

2.4

2.2

6.88e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9635486

Infection with Mycobacterium tuberculosis

3 of 87

1.16

0.64

0.0276

MAP-5663205

Infectious disease

3 of 89

1.15

0.64

0.0276

MAP-1643685

Disease

3 of 97

1.11

0.62

0.0276

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005847

mRNA cleavage and polyadenylation specificity factor complex

2 of 2

2.62

1.33

0.0037

GOCC:0005654

Nucleoplasm

3 of 21

1.78

1.2

0.0037

GOCC:0000428

DNA-directed RNA polymerase complex

4 of 63

1.42

1.04

0.0037

GOCC:0032991

Protein-containing complex

6 of 501

0.7

0.48

0.0113

GOCC:0005622

Intracellular

9 of 1374

0.44

0.32

0.0122

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0240

DNA-directed RNA polymerase

3 of 5

2.4

2.08

0.00012

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