KJS21246.1 protein (Clostridiaceae bacterium BRHc20a)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

KJS21246.1

Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (484 aa)

Predicted Functional Partners:

KJS21247.1

0.985

KJS20557.1

0.963

KJS20564.1

0.962

KJS19104.1

0.952

KJS19575.1

0.939

KJS22681.1

0.938

KJS22239.1

0.938

KJS21765.1

0.938

KJS21638.1

0.938

KJS19141.1

0.938

Your Current Organism:

Clostridiaceae bacterium BRHc20a

NCBI taxonomy Id: 1629719
Other names: C. bacterium BRH_c20a, Clostridiaceae bacterium BRH_c20a

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KJS19104.1	KJS19141.1	VR72_20470	VR72_19130	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Chemotaxis protein CheY; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.846
KJS19104.1	KJS19575.1	VR72_20470	VR72_18150	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.846
KJS19104.1	KJS20557.1	VR72_20470	VR72_14240	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
KJS19104.1	KJS20564.1	VR72_20470	VR72_14290	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
KJS19104.1	KJS21246.1	VR72_20470	VR72_11530	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.952
KJS19104.1	KJS21247.1	VR72_20470	VR72_11535	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.846
KJS19104.1	KJS21638.1	VR72_20470	VR72_09900	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.846
KJS19104.1	KJS21765.1	VR72_20470	VR72_08905	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Chemotaxis protein CheY; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.846
KJS19104.1	KJS22239.1	VR72_20470	VR72_06875	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.846
KJS19104.1	KJS22681.1	VR72_20470	VR72_04935	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.846
KJS19141.1	KJS19104.1	VR72_19130	VR72_20470	Chemotaxis protein CheY; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.846
KJS19141.1	KJS20557.1	VR72_19130	VR72_14240	Chemotaxis protein CheY; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.991
KJS19141.1	KJS20564.1	VR72_19130	VR72_14290	Chemotaxis protein CheY; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.959
KJS19141.1	KJS21246.1	VR72_19130	VR72_11530	Chemotaxis protein CheY; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.938
KJS19575.1	KJS19104.1	VR72_18150	VR72_20470	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.846
KJS19575.1	KJS20557.1	VR72_18150	VR72_14240	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.991
KJS19575.1	KJS20564.1	VR72_18150	VR72_14290	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.959
KJS19575.1	KJS21246.1	VR72_18150	VR72_11530	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.939
KJS20557.1	KJS19104.1	VR72_14240	VR72_20470	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
KJS20557.1	KJS19141.1	VR72_14240	VR72_19130	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Chemotaxis protein CheY; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.991

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

53

average node degree:

9.64

avg. local clustering coefficient:

0.968

expected number of edges:

33

PPI enrichment p-value:

0.000683

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0018106

Peptidyl-histidine phosphorylation

6 of 25

1.88

3.02

8.67e-08

GO:0007165

Signal transduction

6 of 58

1.51

1.99

2.83e-06

GO:0050896

Response to stimulus

11 of 236

1.17

1.71

2.41e-10

GO:0000160

Phosphorelay signal transduction system

3 of 46

1.31

0.69

0.0287

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004673

Protein histidine kinase activity

7 of 26

1.93

3.76

7.90e-10

GO:0016772

Transferase activity, transferring phosphorus-containing groups

9 of 143

1.3

1.96

4.11e-09

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016021

Integral component of membrane

9 of 671

0.63

0.49

0.0019

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3210

PAS-associated, C-terminal, and cheY-homologous receiver domain

10 of 15

2.32

7.99

3.66e-19

CL:3213

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain, and Cell pole

8 of 10

2.4

6.93

1.56e-15

CL:3205

Signal transduction, and PAS fold-4

11 of 34

2.01

6.46

3.66e-19

CL:3216

PAS-associated, C-terminal, and WD40/YVTN repeat-like-containing domain superfamily

5 of 5

2.5

4.5

1.57e-09

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02020

Two-component system

10 of 255

1.09

1.44

7.16e-09

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0597

Phosphoprotein

9 of 46

1.79

4.18

3.52e-13

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR011006

CheY-like superfamily

9 of 37

1.88

4.53

3.88e-13

IPR001789

Signal transduction response regulator, receiver domain

9 of 37

1.88

4.53

3.88e-13

IPR003661

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain

7 of 21

2.02

4.21

1.40e-10

IPR036097

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily

7 of 22

2.0

4.16

1.40e-10

IPR005467

Histidine kinase domain

7 of 24

1.96

4.03

1.85e-10

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00448

cheY-homologous receiver domain

9 of 35

1.91

4.91

2.15e-14

SM00388

His Kinase A (phosphoacceptor) domain

7 of 22

2.0

4.4

2.37e-11

SM00387

Histidine kinase-like ATPases

7 of 26

1.93

4.13

4.31e-11

SM00091

PAS domain

3 of 10

1.98

1.84

0.00019

SM00086

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)

2 of 5

2.1

1.24

0.0043

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