KJS20453.1 protein (Clostridiaceae bacterium BRHc20a)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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[Homology]

Score

KJS20453.1

Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (570 aa)

Predicted Functional Partners:

KJS20452.1

0.956

KJS20454.1

0.956

KJS20455.1

0.762

KJS20451.1

0.642

KJS20510.1

0.625

KJS19566.1

0.445

Your Current Organism:

Clostridiaceae bacterium BRHc20a

NCBI taxonomy Id: 1629719
Other names: C. bacterium BRH_c20a, Clostridiaceae bacterium BRH_c20a

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KJS19566.1	KJS20453.1	VR72_18100	VR72_14555	ATPase AAA; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.445
KJS19566.1	KJS20454.1	VR72_18100	VR72_14560	ATPase AAA; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.419
KJS20451.1	KJS20452.1	VR72_14545	VR72_14550	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.642
KJS20451.1	KJS20453.1	VR72_14545	VR72_14555	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.642
KJS20451.1	KJS20454.1	VR72_14545	VR72_14560	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.642
KJS20451.1	KJS20455.1	VR72_14545	VR72_14565	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.633
KJS20451.1	KJS20510.1	VR72_14545	VR72_14570	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Phosphohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.524
KJS20452.1	KJS20451.1	VR72_14550	VR72_14545	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.642
KJS20452.1	KJS20453.1	VR72_14550	VR72_14555	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.956
KJS20452.1	KJS20454.1	VR72_14550	VR72_14560	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.956
KJS20452.1	KJS20455.1	VR72_14550	VR72_14565	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.772
KJS20452.1	KJS20510.1	VR72_14550	VR72_14570	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Phosphohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.625
KJS20453.1	KJS19566.1	VR72_14555	VR72_18100	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	ATPase AAA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.445
KJS20453.1	KJS20451.1	VR72_14555	VR72_14545	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.642
KJS20453.1	KJS20452.1	VR72_14555	VR72_14550	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.956
KJS20453.1	KJS20454.1	VR72_14555	VR72_14560	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.956
KJS20453.1	KJS20455.1	VR72_14555	VR72_14565	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.762
KJS20453.1	KJS20510.1	VR72_14555	VR72_14570	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Phosphohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.625
KJS20454.1	KJS19566.1	VR72_14560	VR72_18100	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	ATPase AAA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.419
KJS20454.1	KJS20451.1	VR72_14560	VR72_14545	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.642

page 1 of 2

Network Stats

number of nodes:

6

number of edges:

13

average node degree:

4.33

avg. local clustering coefficient:

0.9

expected number of edges:

5

PPI enrichment p-value:

0.00201

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009168

Purine ribonucleoside monophosphate biosynthetic process

7 of 18

1.88

3.49

2.80e-09

GO:0006189

De novo IMP biosynthetic process

6 of 13

1.96

3.49

8.61e-09

GO:0009152

Purine ribonucleotide biosynthetic process

7 of 35

1.6

2.69

8.99e-09

GO:0009260

Ribonucleotide biosynthetic process

8 of 47

1.53

2.6

2.80e-09

GO:0044208

De novo AMP biosynthetic process

2 of 2

2.29

1.42

0.0022

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016879

Ligase activity, forming carbon-nitrogen bonds

5 of 35

1.45

1.4

0.00029

GO:0016742

Hydroxymethyl-, formyl- and related transferase activity

2 of 3

2.12

0.81

0.0319

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005829

Cytosol

5 of 98

1.0

0.75

0.0039

GO:0005622

Intracellular anatomical structure

11 of 680

0.5

0.43

0.00030

GO:0005737

Cytoplasm

9 of 557

0.5

0.38

0.0055

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:946

De novo IMP biosynthetic process

7 of 11

2.1

4.44

8.92e-11

CL:828

Cellular amino acid biosynthetic process, and Ribonucleoside monophosphate biosynthetic process

8 of 105

1.18

1.48

4.72e-07

CL:948

Phosphoribosylformylglycinamidine synthase activity, and PurE domain

2 of 6

1.82

0.78

0.0315

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00230

Purine metabolism

7 of 45

1.49

2.25

8.35e-08

map00670

One carbon pool by folate

2 of 6

1.82

0.93

0.0149

map00250

Alanine, aspartate and glutamate metabolism

3 of 25

1.37

0.84

0.0125

map01110

Biosynthesis of secondary metabolites

7 of 313

0.64

0.44

0.0125

map01100

Metabolic pathways

9 of 679

0.42

0.31

0.0160

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0658

Purine biosynthesis

5 of 11

1.95

2.81

6.58e-07

KW-0436

Ligase

5 of 56

1.25

1.16

0.00040

KW-0460

Magnesium

4 of 45

1.24

0.96

0.0030

KW-0315

Glutamine amidotransferase

2 of 12

1.52

0.64

0.0496

KW-0547

Nucleotide-binding

5 of 145

0.83

0.54

0.0162

(more ...)

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