Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
CL1_0085Competence damage-inducible protein A; COG1058; Belongs to the CinA family. (252 aa)    
Predicted Functional Partners:
CL1_0084
Translation initiation factor IF-2B subunit alpha; COG1184; Belongs to the eIF-2B alpha/beta/delta subunits family.
       0.886
gap
Putative glyceraldehyde-3-phosphate dehydrogenase; COG0057.
 
     0.831
CL1_0568
Aspartate/glutamate/uridylate kinase; Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids.
       0.658
mvk
Mevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
       0.658
hisI
Hypothetical protein; COG0139; In the N-terminal section; belongs to the PRA-CH family.
     
 0.653
CL1_1475
Glucose-1-phosphate thymidylyltransferase-like protein; COG1213; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
 
  
 0.561
CL1_0570
Hypothetical protein; COG1355; Belongs to the MEMO1 family.
       0.523
CL1_1535
CDP-alcohol phosphatidyltransferase; COG0558; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
  
  
 0.501
radB
DNA repair and recombination protein RadB; Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange.
 
  
 0.407
Your Current Organism:
Thermococcus cleftensis
NCBI taxonomy Id: 163003
Other names: DSM 27260, KACC 17922, T. cleftensis, Thermococcus cleftensis Hensley et al. 2014, Thermococcus sp. CL1, strain CL1
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.