Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
CL1_0094Na+-driven multidrug efflux pump protein; COG0534. (456 aa)    
Predicted Functional Partners:
CL1_0095
Hypothetical protein.
       0.857
rpl37e
50S ribosomal protein L37e; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL37 family.
   
 
 0.847
CL1_0092
Small nuclear ribonucleoprotein; COG1958; Belongs to the snRNP Sm proteins family.
       0.817
CL1_0096
Hypothetical protein containing PIN domain 1; COG4113.
       0.795
glyS
glycyl-tRNA synthetase; Catalyzes the attachment of glycine to tRNA(Gly).
       0.563
gap
Putative glyceraldehyde-3-phosphate dehydrogenase; COG0057.
  
  
 0.544
tbp
TATA-box binding protein; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.
   
    0.539
CL1_1677
ABC type multidrug transporter permease; COG0842.
  
  
 0.461
rpl15
50S ribosomal protein L15P; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family.
    
   0.419
CL1_0334
Multidrug ABC transporter ATPase 1; COG1131.
  
  
 0.416
Your Current Organism:
Thermococcus cleftensis
NCBI taxonomy Id: 163003
Other names: DSM 27260, KACC 17922, T. cleftensis, Thermococcus cleftensis Hensley et al. 2014, Thermococcus sp. CL1, strain CL1
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