Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
CL1_0182Hypothetical protein; COG1817. (375 aa)    
Predicted Functional Partners:
CL1_0184
Putative UDP-N-acetylglucosamine 2-epimerase; COG0381.
 
    0.824
CL1_0183
Putative UDP-N-acetyl-D-mannosaminuronate dehydrogenase; COG0677; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
 
   
 0.624
CL1_1169
Protein kinase-like protein; COG2112.
  
     0.621
CL1_1126
RNA-binding protein containing THUMP domain; COG1818.
  
     0.564
CL1_1418
Hypothetical protein; COG2247.
  
    0.523
CL1_0602
Hypothetical protein; COG1422.
  
     0.504
CL1_0230
Ribosomal biogenesis protein; Probably involved in the biogenesis of the ribosome.
  
     0.479
rnp3
Ribonuclease P protein component 3; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 3 family.
  
     0.470
priS
DNA primase small subunit; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. [...]
  
     0.464
CL1_1942
COG1409.
  
     0.458
Your Current Organism:
Thermococcus cleftensis
NCBI taxonomy Id: 163003
Other names: DSM 27260, KACC 17922, T. cleftensis, Thermococcus cleftensis Hensley et al. 2014, Thermococcus sp. CL1, strain CL1
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