Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Score
queEHypothetical protein containing SAM domain 2; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (253 aa)    
Predicted Functional Partners:
queC
Hypothetical protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family.
 
 
 0.996
CL1_1780
Putative 6-pyruvoyl-tetrahydropterin synthase; COG0720.
 
 
 0.988
CL1_0818
Anaerobic ribonucleoside triphosphate reductase; COG1328.
 
 
 0.934
CL1_0226
Hypothetical protein; COG2815.
       0.916
CL1_0224
Hypothetical protein; COG2972.
       0.910
CL1_0002
6-pyruvoyl-tetrahydropterin synthase; COG0720.
  
  
 0.859
CL1_0227
Hypothetical protein.
       0.855
kptA
RNA 2'-phosphotransferase-like protein; Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''- cyclic phosphate (APPR>P). May function as an ADP-ribosylase.
      
 0.815
CL1_0223
Putative TBP-interacting protein DNA helicase Tip49-like protein; COG1224.
       0.664
CL1_1326
Hypothetical protein; COG2029.
 
     0.595
Your Current Organism:
Thermococcus cleftensis
NCBI taxonomy Id: 163003
Other names: DSM 27260, KACC 17922, T. cleftensis, Thermococcus cleftensis Hensley et al. 2014, Thermococcus sp. CL1, strain CL1
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