STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
CL1_0254Ornithine carbamoyltransferase; COG0078; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (286 aa)    
Predicted Functional Partners:
CL1_1208
Carbamate kinase-like carbamoyl phosphate synthetase; COG0549; Belongs to the carbamate kinase family.
 
  
 0.931
CL1_0882
Glycogen synthase; COG0297.
  
  
 0.923
CL1_1762
Putative acetylornithine deacetylase; COG0624.
    
 0.916
pyrC
Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
 
  
 0.915
CL1_0412
Alpha-glucan phosphorylase; COG0058.
  
  
 0.900
pyrB
Aspartate carbamoyltransferase catalytic subunit; COG0540.
 
  
0.823
pyrI
Aspartate carbamoyltransferase regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase.
    
  0.807
CL1_0256
Hypothetical protein; COG0144; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
     
 0.782
thyX
Putative thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
 
     0.764
CL1_0255
Putative ATPase (AAA+ superfamily) 3; COG1672.
       0.631
Your Current Organism:
Thermococcus cleftensis
NCBI taxonomy Id: 163003
Other names: DSM 27260, KACC 17922, T. cleftensis, Thermococcus cleftensis Hensley et al. 2014, Thermococcus sp. CL1, strain CL1
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