Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene co-occurrence
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thiLThiamine monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (322 aa)    
Predicted Functional Partners:
CL1_0035
Putative phosphomethylpyrimidine kinase; COG1992.
 
  
 0.974
CL1_0269
Phosphohydrolase; COG1379.
       0.916
CL1_0268
Chloride channel protein; COG0038.
       0.912
adk
Putative adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.
    
  0.901
CL1_0540
Hypothetical protein; COG2019.
     
  0.900
adkA
Putative adenylate kinase; COG2019; Belongs to the archaeal adenylate kinase family.
     
  0.900
CL1_1773
Hypothetical protein; Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency; Belongs to the THEP1 NTPase family.
     
  0.900
CL1_0271
Hypothetical protein; COG0392.
       0.839
CL1_0273
Putative glycoside hydrolase/deacetylase; COG0726.
       0.839
CL1_0274
Putative pyruvate-formate lyase-activating enzyme; COG1180.
       0.819
Your Current Organism:
Thermococcus cleftensis
NCBI taxonomy Id: 163003
Other names: DSM 27260, KACC 17922, T. cleftensis, Thermococcus cleftensis Hensley et al. 2014, Thermococcus sp. CL1, strain CL1
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