Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
CL1_0333Hypothetical protein; COG1277. (289 aa)    
Predicted Functional Partners:
CL1_0334
Multidrug ABC transporter ATPase 1; COG1131.
  
 
 0.862
CL1_0331
GHMP kinase 1; Catalyzes the condensation of 4-aminobenzoate (pABA) with 5- phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta- ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).
       0.806
CL1_0332
Archeal type N-glycosylase/DNA lyase; DNA repair enzyme that is part of the base excision repair (BER) pathway; protects from oxidative damage by removing the major product of DNA oxidation, 8-oxoguanine (GO), from single- and double- stranded DNA substrates.
       0.806
CL1_1979
Hypothetical protein; COG1277.
 
    
0.707
CL1_0335
Hypothetical protein.
       0.623
CL1_1980
Hypothetical protein; COG1470.
 
    0.512
CL1_0329
Dihydropteroate synthase; COG0294.
       0.427
CL1_1981
ABC type multidrug transporter ATPase 4; COG1131.
  
 
 0.420
Your Current Organism:
Thermococcus cleftensis
NCBI taxonomy Id: 163003
Other names: DSM 27260, KACC 17922, T. cleftensis, Thermococcus cleftensis Hensley et al. 2014, Thermococcus sp. CL1, strain CL1
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