STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tdhL-threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. (350 aa)    
Predicted Functional Partners:
CL1_1311
2-amino-3-ketobutyrate coenzyme A ligase; COG0156.
 
 
 0.975
CL1_0537
Threonine synthase 1; COG0498.
  
 
 0.906
CL1_1302
Threonine synthase 2; COG0498.
   
 
 0.905
CL1_1342
Hypothetical protein containing HAD-like domain 7; COG0463.
  
  
 0.738
pheS
phenylalanyl-tRNA synthetase alpha subunit; COG0016; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
     
 0.679
pheT
phenylalanyl-tRNA synthetase beta subunit; COG0072.
       0.649
CL1_0240
Hypothetical protein containing NADP-dependent oxidoreductase domain; COG0656.
  
 
 0.629
CL1_0344
Hypothetical protein; COG0455.
       0.626
CL1_0345
Arcaheal type Hydroxymethylglutaryl-CoA reductase; COG1257; Belongs to the HMG-CoA reductase family.
     
 0.621
CL1_1601
Asparagine synthase; COG0367.
 
  
 0.615
Your Current Organism:
Thermococcus cleftensis
NCBI taxonomy Id: 163003
Other names: DSM 27260, KACC 17922, T. cleftensis, Thermococcus cleftensis Hensley et al. 2014, Thermococcus sp. CL1, strain CL1
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