Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
CL1_0344Hypothetical protein; COG0455. (247 aa)    
Predicted Functional Partners:
CL1_0345
Arcaheal type Hydroxymethylglutaryl-CoA reductase; COG1257; Belongs to the HMG-CoA reductase family.
 
     0.912
tdh
L-threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family.
       0.831
pheS
phenylalanyl-tRNA synthetase alpha subunit; COG0016; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
       0.782
pheT
phenylalanyl-tRNA synthetase beta subunit; COG0072.
       0.764
atpC
V-type ATP synthase subunit C; Produces ATP from ADP in the presence of a proton gradient across the membrane.
 
   
 0.484
engB
GTP-binding protein 1; Necessary for normal cell division and for the maintenance of normal septation.
 
   
 0.475
CL1_0341
Hypothetical protein; COG2200.
       0.410
CL1_0630
Hypothetical protein; COG1423.
     
 0.408
CL1_0934
V-type ATP synthase subunit K; COG0636.
     
 0.408
CL1_1468
Hypothetical protein; COG1192.
 
  
 0.404
Your Current Organism:
Thermococcus cleftensis
NCBI taxonomy Id: 163003
Other names: DSM 27260, KACC 17922, T. cleftensis, Thermococcus cleftensis Hensley et al. 2014, Thermococcus sp. CL1, strain CL1
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.