STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CL1_0345Arcaheal type Hydroxymethylglutaryl-CoA reductase; COG1257; Belongs to the HMG-CoA reductase family. (406 aa)    
Predicted Functional Partners:
CL1_1403
Putative 3-hydroxy-3-methylglutaryl CoA synthase-like protein; COG3425; Belongs to the thiolase-like superfamily. UPF0219 family.
 
 0.999
mvk
Mevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
 
 0.980
CL1_0344
Hypothetical protein; COG0455.
 
     0.808
CL1_0684
Pyrazinamidase/nicotinamidase-like protein; COG1335.
    
 0.747
CL1_1404
acetyl-CoA acetyltransferase; COG0183.
 
  
 0.705
CL1_0563
Bifunctional short chain isoprenyl diphosphate synthase; COG0142; Belongs to the FPP/GGPP synthase family.
  
 
 0.691
tdh
L-threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family.
     
 0.621
fni
Isopentenyl pyrophosphate isomerase; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
 
   
 0.587
gap
Putative glyceraldehyde-3-phosphate dehydrogenase; COG0057.
     
 0.542
pheT
phenylalanyl-tRNA synthetase beta subunit; COG0072.
       0.508
Your Current Organism:
Thermococcus cleftensis
NCBI taxonomy Id: 163003
Other names: DSM 27260, KACC 17922, T. cleftensis, Thermococcus cleftensis Hensley et al. 2014, Thermococcus sp. CL1, strain CL1
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