Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
CL1_0350Hypothetical protein; COG1885; Belongs to the UPF0212 family. (126 aa)    
Predicted Functional Partners:
CL1_0351
Hypothetical protein; COG1849.
       0.915
pyrG
CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
       0.751
CL1_0692
Hypothetical protein; COG1107.
  
     0.647
CL1_1576
Hypothetical protein; COG2117.
  
    0.612
CL1_0646
Hypothetical protein containing metal dependent hydrolase domain; COG1831.
 
     0.606
CL1_1006
Hypothetical protein; COG2433.
  
     0.601
CL1_1646
Hypothetical protein; COG1967.
  
     0.571
CL1_0132
Phosphoesterase; COG0618.
  
     0.569
CL1_1187
DNA-binding protein, Tfx type; COG1356.
  
     0.560
CL1_1362
Putative transcriptional regulator; COG1709.
  
     0.548
Your Current Organism:
Thermococcus cleftensis
NCBI taxonomy Id: 163003
Other names: DSM 27260, KACC 17922, T. cleftensis, Thermococcus cleftensis Hensley et al. 2014, Thermococcus sp. CL1, strain CL1
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