| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CL1_0159 | CL1_1313 | CL1_0159 | CL1_1313 | Putative RNA-binding protein containing THUMP domain; COG1818. | Replication factor C small subunit; COG1372. | 0.537 |
| CL1_0159 | CL1_1357 | CL1_0159 | CL1_1357 | Putative RNA-binding protein containing THUMP domain; COG1818. | Hypothetical protein; COG2248; Belongs to the UPF0282 family. | 0.572 |
| CL1_0159 | rgy | CL1_0159 | CL1_0370 | Putative RNA-binding protein containing THUMP domain; COG1818. | Reverse gyrase; Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication; In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family. | 0.478 |
| CL1_0369 | CL1_0371 | CL1_0369 | CL1_0371 | Transcription regulator, TrmB family 1; COG1378. | Hypothetical protein. | 0.419 |
| CL1_0369 | rgy | CL1_0369 | CL1_0370 | Transcription regulator, TrmB family 1; COG1378. | Reverse gyrase; Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication; In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family. | 0.528 |
| CL1_0371 | CL1_0369 | CL1_0371 | CL1_0369 | Hypothetical protein. | Transcription regulator, TrmB family 1; COG1378. | 0.419 |
| CL1_0371 | CL1_0372 | CL1_0371 | CL1_0372 | Hypothetical protein. | Hypothetical protein; COG0303. | 0.641 |
| CL1_0371 | rgy | CL1_0371 | CL1_0370 | Hypothetical protein. | Reverse gyrase; Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication; In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family. | 0.692 |
| CL1_0372 | CL1_0371 | CL1_0372 | CL1_0371 | Hypothetical protein; COG0303. | Hypothetical protein. | 0.641 |
| CL1_0372 | rgy | CL1_0372 | CL1_0370 | Hypothetical protein; COG0303. | Reverse gyrase; Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication; In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family. | 0.520 |
| CL1_0943 | rgy | CL1_0943 | CL1_0370 | Hypothetical protein containing KaiC-domain; COG0467; Belongs to the UPF0273 family. | Reverse gyrase; Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication; In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family. | 0.417 |
| CL1_1313 | CL1_0159 | CL1_1313 | CL1_0159 | Replication factor C small subunit; COG1372. | Putative RNA-binding protein containing THUMP domain; COG1818. | 0.537 |
| CL1_1313 | rgy | CL1_1313 | CL1_0370 | Replication factor C small subunit; COG1372. | Reverse gyrase; Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication; In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family. | 0.671 |
| CL1_1357 | CL1_0159 | CL1_1357 | CL1_0159 | Hypothetical protein; COG2248; Belongs to the UPF0282 family. | Putative RNA-binding protein containing THUMP domain; COG1818. | 0.572 |
| CL1_1357 | rgy | CL1_1357 | CL1_0370 | Hypothetical protein; COG2248; Belongs to the UPF0282 family. | Reverse gyrase; Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication; In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family. | 0.434 |
| CL1_1407 | rgy | CL1_1407 | CL1_0370 | Putative acetyltransferase, GNAT family; COG0454. | Reverse gyrase; Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication; In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family. | 0.405 |
| CL1_1773 | rgy | CL1_1773 | CL1_0370 | Hypothetical protein; Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency; Belongs to the THEP1 NTPase family. | Reverse gyrase; Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication; In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family. | 0.490 |
| fbp | rgy | CL1_1205 | CL1_0370 | Fructose-1,6-bisphosphatase; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). | Reverse gyrase; Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication; In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family. | 0.417 |
| rgy | CL1_0159 | CL1_0370 | CL1_0159 | Reverse gyrase; Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication; In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family. | Putative RNA-binding protein containing THUMP domain; COG1818. | 0.478 |
| rgy | CL1_0369 | CL1_0370 | CL1_0369 | Reverse gyrase; Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication; In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family. | Transcription regulator, TrmB family 1; COG1378. | 0.528 |