STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pckGPhosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. (625 aa)    
Predicted Functional Partners:
CL1_0587
Enolase-like protein; COG0148.
  
  
 0.933
eno
Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
  
  
 0.932
CL1_1805
Pyruvate carboxylase subunit B; COG5016.
    
 0.928
CL1_1896
Pyruvate kinase; COG0469; Belongs to the pyruvate kinase family.
  
 
 0.927
CL1_0508
Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family.
     
 0.909
CL1_0657
methylmalonyl-CoA decarboxylase subunit beta; COG1883.
    
 0.900
CL1_0009
2-oxoglutarate ferredoxin oxidoreductase subunit alpha 1; COG0674.
   
 
 0.871
CL1_0012
2-oxoglutarate ferredoxin oxidoreductase subunit alpha 2; COG0674.
   
 
 0.871
CL1_1244
Pyruvate ferredoxin oxidoreductase subunit alpha; COG0674.
   
 
 0.871
CL1_1249
Pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; COG1014.
   
 
 0.861
Your Current Organism:
Thermococcus cleftensis
NCBI taxonomy Id: 163003
Other names: DSM 27260, KACC 17922, T. cleftensis, Thermococcus cleftensis Hensley et al. 2014, Thermococcus sp. CL1, strain CL1
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