STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hypAHydrogenase nickel incorporation protein HypA/HybF; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. (139 aa)    
Predicted Functional Partners:
CL1_0482
Hypothetical protein; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family.
   
   0.912
CL1_0483
Hydrogenase maturation protease; COG0680.
 
  
 0.860
CL1_1151
Coenzyme F420 hydrogenase subunit alpha (frhA); COG3259.
 
 
 0.828
CL1_0486
Hydrogenase expression/formation protein hypD; COG0409.
 
  
 0.786
CL1_0487
Hydrogenase maturation protein HypF; COG0068.
 
   
 0.766
CL1_0485
Hydrogenase expression/formation protein HypC; COG0298.
 
  
 0.738
CL1_0644
Sulfhydrogenase II, alpha chain; COG3259.
 
 
 0.708
CL1_0144
Cytosolic NiFe-hydrogenase subunit alpha; COG3259.
 
 
 0.703
CL1_1367
Putative ferredoxin; COG1142.
  
  
 0.658
CL1_1131
NADH-ubiquinone oxidoreductase subunit 2; COG3261.
 
 
 0.652
Your Current Organism:
Thermococcus cleftensis
NCBI taxonomy Id: 163003
Other names: DSM 27260, KACC 17922, T. cleftensis, Thermococcus cleftensis Hensley et al. 2014, Thermococcus sp. CL1, strain CL1
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