Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
CL1_0537Threonine synthase 1; COG0498. (443 aa)    
Predicted Functional Partners:
tdh
L-threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family.
  
 
 0.911
CL1_1302
Threonine synthase 2; COG0498.
 
  
 
0.911
CL1_0659
Homoserine dehydrogenase; COG0460.
 
 
 0.891
CL1_0538
Hypothetical protein containing KH domain; COG1782.
       0.871
psmB
Proteasome subunit beta 1; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
       0.849
hisI
Hypothetical protein; COG0139; In the N-terminal section; belongs to the PRA-CH family.
 
  
 0.770
rpiA
Ribose-5-phosphate isomerase, type A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
  
  
 0.757
CL1_0536
Hypothetical protein.
       0.727
CL1_1601
Asparagine synthase; COG0367.
 
  
 0.693
CL1_1261
D-3-phosphoglycerate dehydrogenase; COG0111; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
 
  
 0.576
Your Current Organism:
Thermococcus cleftensis
NCBI taxonomy Id: 163003
Other names: DSM 27260, KACC 17922, T. cleftensis, Thermococcus cleftensis Hensley et al. 2014, Thermococcus sp. CL1, strain CL1
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