STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
psmBProteasome subunit beta 1; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. (203 aa)    
Predicted Functional Partners:
CL1_0538
Hypothetical protein containing KH domain; COG1782.
     
 0.946
psmA
Proteasome subunit alpha; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
 
 
0.914
psmB-2
Proteasome subunit beta 2; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
  
  
 
0.905
rpiA
Ribose-5-phosphate isomerase, type A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
     
 0.863
CL1_0536
Hypothetical protein.
       0.863
CL1_0537
Threonine synthase 1; COG0498.
       0.849
pan
Proteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase- [...]
  
 0.849
CL1_0540
Hypothetical protein; COG2019.
       0.835
CL1_0541
Hypothetical protein containing ion transport domain; COG1226.
       0.555
CL1_0154
Metalloprotease containing JAB1/MPN domain; COG1310.
   
 0.541
Your Current Organism:
Thermococcus cleftensis
NCBI taxonomy Id: 163003
Other names: DSM 27260, KACC 17922, T. cleftensis, Thermococcus cleftensis Hensley et al. 2014, Thermococcus sp. CL1, strain CL1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.