Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
CL1_0541Hypothetical protein containing ion transport domain; COG1226. (112 aa)    
Predicted Functional Partners:
CL1_0540
Hypothetical protein; COG2019.
       0.802
psmB
Proteasome subunit beta 1; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
       0.555
CL1_0538
Hypothetical protein containing KH domain; COG1782.
       0.551
CL1_0537
Threonine synthase 1; COG0498.
       0.527
rpiA
Ribose-5-phosphate isomerase, type A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
       0.449
CL1_0536
Hypothetical protein.
       0.449
Your Current Organism:
Thermococcus cleftensis
NCBI taxonomy Id: 163003
Other names: DSM 27260, KACC 17922, T. cleftensis, Thermococcus cleftensis Hensley et al. 2014, Thermococcus sp. CL1, strain CL1
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