STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CL1_0568Aspartate/glutamate/uridylate kinase; Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids. (263 aa)    
Predicted Functional Partners:
fni
Isopentenyl pyrophosphate isomerase; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
 
  
  0.973
CL1_0563
Bifunctional short chain isoprenyl diphosphate synthase; COG0142; Belongs to the FPP/GGPP synthase family.
    
 0.937
mvk
Mevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
 
   
 0.881
CL1_0570
Hypothetical protein; COG1355; Belongs to the MEMO1 family.
       0.696
CL1_0567
Hypothetical protein; COG1003.
       0.658
rnj
Hypothetical protein containing metallo-beta-lactamase superfamily; An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation; Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.
 
     0.603
CL1_1403
Putative 3-hydroxy-3-methylglutaryl CoA synthase-like protein; COG3425; Belongs to the thiolase-like superfamily. UPF0219 family.
  
   
 0.527
CL1_0571
Uridine phosphorylase (udp); Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.
       0.503
CL1_1482
Hypothetical protein containing ribokinase-like domain 3; COG0524.
  
   
 0.475
CL1_1009
Hypothetical protein; COG4043.
  
     0.447
Your Current Organism:
Thermococcus cleftensis
NCBI taxonomy Id: 163003
Other names: DSM 27260, KACC 17922, T. cleftensis, Thermococcus cleftensis Hensley et al. 2014, Thermococcus sp. CL1, strain CL1
Server load: low (38%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.