Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
CL1_0578Hypothetical protein; COG0727. (166 aa)    
Predicted Functional Partners:
CL1_0577
Putative transcription regulator, Lrp/AsnC family; COG1522.
 
     0.939
srp54
Signal recognition particle protein SRP54; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily.
  
    0.917
CL1_0579
Hypothetical protein containing phosphoribosyltransferase-lilke domain 1; COG0503.
       0.858
CL1_0580
Hypothetical protein; COG1793.
       0.858
CL1_0575
Hypothetical protein.
       0.487
CL1_1073
Hypothetical protein; COG1673; Belongs to the UPF0310 family.
  
     0.459
CL1_1595
Nucleotidyltransferase; COG2413.
  
     0.456
CL1_1169
Protein kinase-like protein; COG2112.
  
     0.445
CL1_0159
Putative RNA-binding protein containing THUMP domain; COG1818.
  
     0.427
Your Current Organism:
Thermococcus cleftensis
NCBI taxonomy Id: 163003
Other names: DSM 27260, KACC 17922, T. cleftensis, Thermococcus cleftensis Hensley et al. 2014, Thermococcus sp. CL1, strain CL1
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.