Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
CL1_0684Pyrazinamidase/nicotinamidase-like protein; COG1335. (181 aa)    
Predicted Functional Partners:
CL1_1355
Nicotinate phosphoribosyltransferase; COG1488.
 
 0.978
cobB
NAD-dependent deacetylase; COG0846; Belongs to the sirtuin family. Class III subfamily.
   
 0.920
CL1_0685
Hypothetical protein; COG2886.
       0.858
CL1_0686
Putative thioesterase; COG2050.
     
 0.819
CL1_0345
Arcaheal type Hydroxymethylglutaryl-CoA reductase; COG1257; Belongs to the HMG-CoA reductase family.
      0.743
CL1_0688
Major facilitator superfamily permease 7; COG0477.
  
    0.603
CL1_0687
Transcription regulator, PadR-like familiy 2; COG1695.
       0.597
hisI
Hypothetical protein; COG0139; In the N-terminal section; belongs to the PRA-CH family.
  
    0.507
CL1_0797
Nicotinate-nucleotide pyrophosphorylase; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.
  
 
 0.479
CL1_1539
Archaeal nicotinamide-nucleotide adenylyltransferase; COG1056.
     
 0.436
Your Current Organism:
Thermococcus cleftensis
NCBI taxonomy Id: 163003
Other names: DSM 27260, KACC 17922, T. cleftensis, Thermococcus cleftensis Hensley et al. 2014, Thermococcus sp. CL1, strain CL1
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