STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
CL1_0706Endonuclease IV; COG0648. (281 aa)    
Predicted Functional Partners:
CL1_0705
Hypothetical protein; COG1658.
     
 0.887
CL1_1375
Hypothetical protein; COG3568.
   
 
 0.880
nth
Hypothetical protein; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
  
 
 0.857
CL1_0703
Hypothetical protein; COG0011.
       0.838
CL1_0704
Hypothetical protein; COG2237.
       0.838
CL1_0702
Hypothetical protein; COG2078.
       0.786
CL1_0698
DNA polymerase, family B; COG0417.
 
 
 
 0.638
CL1_1633
Putative DNA glycosylase; COG0122.
   
 
 0.629
hisI
Hypothetical protein; COG0139; In the N-terminal section; belongs to the PRA-CH family.
     
 0.600
pcn
DNA polymerase sliding clamp protein; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
 
   
 0.501
Your Current Organism:
Thermococcus cleftensis
NCBI taxonomy Id: 163003
Other names: DSM 27260, KACC 17922, T. cleftensis, Thermococcus cleftensis Hensley et al. 2014, Thermococcus sp. CL1, strain CL1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.