STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CL1_0711Putative xanthine/uracil permease 2; COG2252. (445 aa)    
Predicted Functional Partners:
CL1_0105
Hypothetical protein; COG4818.
  
    0.720
CL1_0204
Putative xanthine/uracil permease 1; COG2233.
 
  
 0.650
purL
Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and [...]
  
  
 0.626
purD
Phosphoribosylamine-glycine ligase; COG0151; Belongs to the GARS family.
  
  
 0.621
purE
Phosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
  
  
 0.596
purM
Phosphoribosylformylglycinamidine cyclo-ligase; COG0150.
  
  
 0.592
purQ
Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interac [...]
  
  
 0.548
CL1_0579
Hypothetical protein containing phosphoribosyltransferase-lilke domain 1; COG0503.
  
  
 0.533
purC
Putative phosphoribosylaminoimidazole-succinocarboxamide (SAICAR) synthase; COG0152; Belongs to the SAICAR synthetase family.
  
  
 0.491
purC-2
Phosphoribosylaminoimidazole-succinocarboxamide synthase; COG0152; Belongs to the SAICAR synthetase family.
  
  
 0.491
Your Current Organism:
Thermococcus cleftensis
NCBI taxonomy Id: 163003
Other names: DSM 27260, KACC 17922, T. cleftensis, Thermococcus cleftensis Hensley et al. 2014, Thermococcus sp. CL1, strain CL1
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