Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Score
CL1_0732Hypothetical protein containing fmu domain; COG0144; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (442 aa)    
Predicted Functional Partners:
CL1_0733
Hypothetical protein.
       0.849
CL1_0734
Hypothetical protein; COG2263.
     
 0.810
CL1_0735
Diphthamide synthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family.
  
    0.760
CL1_1027
Hypothetical protein; COG1161.
 
 
 0.666
CL1_0947
Hypothetical protein containing ribosome biogenesis factor; COG1374.
  
 
 0.648
CL1_1401
C/D box methylation guide ribonucleoprotein complex aNOP56 subunit; COG1498.
   
 
 0.628
CL1_0288
Putative GTP-binding protein; COG1084.
   
 
 0.614
rpl18
50S ribosomal protein L18P; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.
  
 
 0.553
tmcA
Hypothetical protein; Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).
  
 
 0.551
rps8e
30S ribosomal protein S8e; COG2007.
  
 
 0.545
Your Current Organism:
Thermococcus cleftensis
NCBI taxonomy Id: 163003
Other names: DSM 27260, KACC 17922, T. cleftensis, Thermococcus cleftensis Hensley et al. 2014, Thermococcus sp. CL1, strain CL1
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