| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CL1_0154 | CL1_0735 | CL1_0154 | CL1_0735 | Metalloprotease containing JAB1/MPN domain; COG1310. | Diphthamide synthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | 0.561 |
| CL1_0154 | eif2b | CL1_0154 | CL1_0653 | Metalloprotease containing JAB1/MPN domain; COG1310. | Translation initiation factor IF-2 subunit beta; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-beta/eIF-5 family. | 0.731 |
| CL1_0154 | rps4e | CL1_0154 | CL1_0615 | Metalloprotease containing JAB1/MPN domain; COG1310. | 30S ribosomal protein S4e; COG1471; Belongs to the eukaryotic ribosomal protein eS4 family. | 0.655 |
| CL1_0733 | CL1_0734 | CL1_0733 | CL1_0734 | Hypothetical protein. | Hypothetical protein; COG2263. | 0.654 |
| CL1_0733 | CL1_0735 | CL1_0733 | CL1_0735 | Hypothetical protein. | Diphthamide synthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | 0.594 |
| CL1_0734 | CL1_0733 | CL1_0734 | CL1_0733 | Hypothetical protein; COG2263. | Hypothetical protein. | 0.654 |
| CL1_0734 | CL1_0735 | CL1_0734 | CL1_0735 | Hypothetical protein; COG2263. | Diphthamide synthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | 0.817 |
| CL1_0735 | CL1_0154 | CL1_0735 | CL1_0154 | Diphthamide synthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Metalloprotease containing JAB1/MPN domain; COG1310. | 0.561 |
| CL1_0735 | CL1_0733 | CL1_0735 | CL1_0733 | Diphthamide synthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Hypothetical protein. | 0.594 |
| CL1_0735 | CL1_0734 | CL1_0735 | CL1_0734 | Diphthamide synthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Hypothetical protein; COG2263. | 0.817 |
| CL1_0735 | CL1_1476 | CL1_0735 | CL1_1476 | Diphthamide synthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Hypothetical protein; COG2102. | 0.675 |
| CL1_0735 | dphB | CL1_0735 | CL1_1363 | Diphthamide synthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.912 |
| CL1_0735 | eif2b | CL1_0735 | CL1_0653 | Diphthamide synthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Translation initiation factor IF-2 subunit beta; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-beta/eIF-5 family. | 0.600 |
| CL1_0735 | fusA | CL1_0735 | CL1_1929 | Diphthamide synthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Elongation factor EF-2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. | 0.973 |
| CL1_0735 | rpl10e | CL1_0735 | CL1_0631 | Diphthamide synthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | 50S ribosomal protein L10E; COG0197; Belongs to the universal ribosomal protein uL16 family. | 0.614 |
| CL1_0735 | rpl37ae | CL1_0735 | CL1_0228 | Diphthamide synthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | 50S ribosomal protein L37Ae; Binds to the 23S rRNA. | 0.579 |
| CL1_0735 | rps4e | CL1_0735 | CL1_0615 | Diphthamide synthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | 30S ribosomal protein S4e; COG1471; Belongs to the eukaryotic ribosomal protein eS4 family. | 0.576 |
| CL1_1476 | CL1_0735 | CL1_1476 | CL1_0735 | Hypothetical protein; COG2102. | Diphthamide synthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | 0.675 |
| CL1_1476 | dphB | CL1_1476 | CL1_1363 | Hypothetical protein; COG2102. | Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.751 |
| CL1_1476 | eif2b | CL1_1476 | CL1_0653 | Hypothetical protein; COG2102. | Translation initiation factor IF-2 subunit beta; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-beta/eIF-5 family. | 0.475 |