STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CL1_0745Putative exonuclease SbcD; COG1407. (216 aa)    
Predicted Functional Partners:
CL1_0746
Transcription regulator, TrmB family 2; COG5625.
       0.623
nusA
Transcription elongation factor NusA-like protein; Participates in transcription termination. Belongs to the NusA family.
  
     0.576
CL1_0900
Hypothetical protein; COG1784.
  
     0.549
endA
tRNA-splicing endonuclease subunit alpha; Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
  
     0.480
CL1_1058
Cell division control protein 6; Involved in regulation of DNA replication.
  
     0.471
CL1_1049
Hypothetical protein; COG1938.
  
     0.448
cca
tRNA CCA-pyrophosphorylase; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
  
     0.441
CL1_0714
Replication factor A; COG1599.
 
     0.428
CL1_0577
Putative transcription regulator, Lrp/AsnC family; COG1522.
  
     0.412
CL1_1174
Hypothetical protein; COG1784.
  
     0.407
Your Current Organism:
Thermococcus cleftensis
NCBI taxonomy Id: 163003
Other names: DSM 27260, KACC 17922, T. cleftensis, Thermococcus cleftensis Hensley et al. 2014, Thermococcus sp. CL1, strain CL1
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