Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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CL1_0764Hypothetical protein containing methylase domain; COG2890. (196 aa)    
Predicted Functional Partners:
prf1
Putative peptide chain release factor 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.
   
 0.842
taw1
tRNA-modifying enzyme; Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
       0.737
CL1_0758
DNA-directed RNA polymerase subunit E; COG1095.
 
     0.698
rps24e
30S ribosomal protein S24e; COG2004; Belongs to the eukaryotic ribosomal protein eS24 family.
   
   0.677
spt4
DNA-directed RNA polymerase subunit E; Stimulates transcription elongation; Belongs to the archaeal Spt4 family.
       0.658
CL1_0760
Hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).
       0.658
rps27ae
30S ribosomal protein S27ae; COG1998; Belongs to the eukaryotic ribosomal protein eS31 family.
       0.658
ppa
Inorganic pyrophosphatase; Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
       0.645
CL1_0763
Subtilisin-like serine protease; COG1404.
     
 0.628
hisI
Hypothetical protein; COG0139; In the N-terminal section; belongs to the PRA-CH family.
       0.567
Your Current Organism:
Thermococcus cleftensis
NCBI taxonomy Id: 163003
Other names: DSM 27260, KACC 17922, T. cleftensis, Thermococcus cleftensis Hensley et al. 2014, Thermococcus sp. CL1, strain CL1
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