STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
CL1_0790Hypothetical protein containing phosphoesterase domain; COG1407. (229 aa)    
Predicted Functional Partners:
CL1_0791
ATP-dependent helicase; COG1201.
 
    0.906
CL1_1766
ATP-dependent helicase, lhr-like protein (lhr); COG1201.
 
    0.709
CL1_0789
Hypothetical protein; COG1819.
       0.701
CL1_0430
Hypothetical protein; COG0188.
       0.658
CL1_0431
Hypothetical protein; COG2339.
       0.658
CL1_0433
Hypothetical protein.
       0.658
CL1_1570
Hypothetical protein; COG1236.
 
     0.658
purM
Phosphoribosylformylglycinamidine cyclo-ligase; COG0150.
       0.614
purT
Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family.
       0.435
lig
ATP-dependent DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair; Belongs to the ATP-dependent DNA ligase family.
 
     0.425
Your Current Organism:
Thermococcus cleftensis
NCBI taxonomy Id: 163003
Other names: DSM 27260, KACC 17922, T. cleftensis, Thermococcus cleftensis Hensley et al. 2014, Thermococcus sp. CL1, strain CL1
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