STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nadEPutative NAD synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (254 aa)    
Predicted Functional Partners:
nadK
NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
    
 0.962
CL1_1539
Archaeal nicotinamide-nucleotide adenylyltransferase; COG1056.
    
 0.946
cobB
NAD-dependent deacetylase; COG0846; Belongs to the sirtuin family. Class III subfamily.
    
 0.938
CL1_0910
Putative drug/metabolite transporter 3; COG0697.
 
     0.839
CL1_1601
Asparagine synthase; COG0367.
 
   
 0.823
CL1_0912
Hypothetical protein.
       0.818
CL1_1355
Nicotinate phosphoribosyltransferase; COG1488.
 
  
 0.798
CL1_0915
Dipeptide/oligopeptide ABC transporter permease 1; COG1173.
 
  
 0.780
CL1_0913
Dipeptide/oligopeptide ABC transporter ATPase 3; COG4608.
       0.741
CL1_0914
Dipeptide/oligopeptide ABC transporter ATPase 4; COG0444.
       0.737
Your Current Organism:
Thermococcus cleftensis
NCBI taxonomy Id: 163003
Other names: DSM 27260, KACC 17922, T. cleftensis, Thermococcus cleftensis Hensley et al. 2014, Thermococcus sp. CL1, strain CL1
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