Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
CL1_0920Hypothetical protein; COG0535. (300 aa)    
Predicted Functional Partners:
pyrK
Dihydroorotate dehydrogenase electron transfer subunit; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).
 
    0.883
pyrC
Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
  
    0.866
CL1_0924
Hypothetical protein; COG0037.
 
     0.865
CL1_0923
Hypothetical protein.
       0.787
CL1_0921
ABC type dipeptide/oligopeptide/nickel transporter permease 1; COG0601.
       0.732
CL1_0159
Putative RNA-binding protein containing THUMP domain; COG1818.
  
     0.646
CL1_0104
Putative ATPase 1; COG0037.
 
     0.616
CL1_1256
Hypothetical protein; COG0457.
 
     0.580
CL1_0922
ABC type dipeptide/oligopeptide/nickel transporter permease 2; COG1173.
  
  
 0.558
CL1_1073
Hypothetical protein; COG1673; Belongs to the UPF0310 family.
  
     0.545
Your Current Organism:
Thermococcus cleftensis
NCBI taxonomy Id: 163003
Other names: DSM 27260, KACC 17922, T. cleftensis, Thermococcus cleftensis Hensley et al. 2014, Thermococcus sp. CL1, strain CL1
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.