Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Score
speHS-adenosylmethionine decarboxylase; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily. (142 aa)    
Predicted Functional Partners:
speE
Spermidine synthase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine; Belongs to the spermidine/spermine synthase family.
 
 0.999
mat
Archaeal S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP; Belongs to the AdoMet synthase 2 family.
  
  
 0.913
CL1_1080
Hypothetical protein; COG0270; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
     
  0.900
CL1_1491
Hypothetical protein; COG0270; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.
     
  0.900
CL1_1545
SAM-dependent methyltransferase 2; COG0500.
    
  0.900
secD
Putative preprotein translocase subunit SecD; Involved in protein export.
  
    0.796
secF
Putative preprotein translocase subunit SecF; Involved in protein export.
  
    0.783
CL1_0937
Trk-type pottasium transport system, NAD-binding component; COG0569.
     
 0.774
CL1_0935
V-type ATP synthase subunit I; COG1269; Belongs to the V-ATPase 116 kDa subunit family.
       0.639
CL1_0936
V-type ATP synthase subunit H.
       0.639
Your Current Organism:
Thermococcus cleftensis
NCBI taxonomy Id: 163003
Other names: DSM 27260, KACC 17922, T. cleftensis, Thermococcus cleftensis Hensley et al. 2014, Thermococcus sp. CL1, strain CL1
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