STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CL1_1151Coenzyme F420 hydrogenase subunit alpha (frhA); COG3259. (390 aa)    
Predicted Functional Partners:
CL1_1150
Coenzyme F420 hydrogenase subunit gamma (frhG); COG1941.
 
 0.999
CL1_1149
Coenzyme F420-reducing hydrogenase subunit beta; COG1035.
 
 0.998
CL1_0643
Sulfhydrogenase II, delta chain; COG1941.
 
 
 0.872
CL1_0143
Cytosolic NiFe-hydrogenase subunit delta; COG1941.
 
 
 0.871
hypA
Hydrogenase nickel incorporation protein HypA/HybF; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
 
 0.828
CL1_0486
Hydrogenase expression/formation protein hypD; COG0409.
 
 
 0.749
CL1_0487
Hydrogenase maturation protein HypF; COG0068.
 
 
 
 0.749
CL1_0485
Hydrogenase expression/formation protein HypC; COG0298.
 
 
 0.715
CL1_0490
Hydrogenase expression/formation protein HypE 2; COG0309.
 
   
 0.656
CL1_1145
Formate transporter; COG2116.
     
 0.609
Your Current Organism:
Thermococcus cleftensis
NCBI taxonomy Id: 163003
Other names: DSM 27260, KACC 17922, T. cleftensis, Thermococcus cleftensis Hensley et al. 2014, Thermococcus sp. CL1, strain CL1
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.