STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CL1_1208Carbamate kinase-like carbamoyl phosphate synthetase; COG0549; Belongs to the carbamate kinase family. (315 aa)    
Predicted Functional Partners:
CL1_0254
Ornithine carbamoyltransferase; COG0078; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
 
  
 0.931
CL1_0909
Glutamine synthetase; COG0174; Belongs to the glutamine synthetase family.
     
 0.924
CL1_0542
Glutamate dehydrogenase; COG0334; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
     
 0.919
purQ
Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interac [...]
    
  0.901
pyrB
Aspartate carbamoyltransferase catalytic subunit; COG0540.
    
 0.887
CL1_1898
Amino acid transporter; COG0531.
  
  
 0.816
pyrI
Aspartate carbamoyltransferase regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase.
    
  0.811
CL1_1209
Hypothetical protein; COG0616.
       0.698
CL1_1207
Hypothetical protein; COG1233.
       0.586
tpiA
Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family.
      
 0.539
Your Current Organism:
Thermococcus cleftensis
NCBI taxonomy Id: 163003
Other names: DSM 27260, KACC 17922, T. cleftensis, Thermococcus cleftensis Hensley et al. 2014, Thermococcus sp. CL1, strain CL1
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