STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CL1_1233Hypothetical protein containing ribokinase-like domain 2; COG0524; Belongs to the carbohydrate kinase PfkB family. (296 aa)    
Predicted Functional Partners:
CL1_0365
Bifunctional D-arabino 3-hexulose-6-phosphate formaldehyde lyase/phosphohexuloisomerase; COG0794.
 
  
 0.736
CL1_1232
Hypothetical protein containing ACT domain 2; COG2150.
       0.632
hisA
1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; COG0106.
  
  
 0.624
CL1_1234
Hypothetical protein; COG1653.
       0.602
CL1_1668
Hypothetical protein containing xylose isomerase domain; COG1082.
 
  
 0.593
CL1_0325
AP endonuclease; COG1082.
 
  
 0.582
CL1_0826
Hypothetical protein containing oxidoreductase-domain; COG0673.
 
  
 0.559
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
  
 
 0.550
CL1_0579
Hypothetical protein containing phosphoribosyltransferase-lilke domain 1; COG0503.
  
 
 0.541
CL1_1185
L-fuculose phosphate aldolase; COG0235.
 
  
 0.453
Your Current Organism:
Thermococcus cleftensis
NCBI taxonomy Id: 163003
Other names: DSM 27260, KACC 17922, T. cleftensis, Thermococcus cleftensis Hensley et al. 2014, Thermococcus sp. CL1, strain CL1
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