STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
CL1_12592-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (302 aa)    
Predicted Functional Partners:
panB
3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family.
   
 0.997
CL1_1196
GHMP kinase 2; COG1829.
 
  
 0.938
CL1_1261
D-3-phosphoglycerate dehydrogenase; COG0111; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
     
 0.895
CL1_1260
Putative phosphate transport regulator; COG1392.
       0.893
CL1_1256
Hypothetical protein; COG0457.
 
     0.863
CL1_1257
Putative methylated-DNA--protein-cysteine methyltransferase; COG0350.
       0.842
CL1_1258
Putative tRNA/rRNA methyltransferase; COG0565.
       0.842
CL1_1262
Fumarate hydratase subunit alpha; COG1951.
       0.796
CL1_1263
Fumarate hydratase subunit beta; COG1838.
  
    0.775
hisI
Hypothetical protein; COG0139; In the N-terminal section; belongs to the PRA-CH family.
     
 0.583
Your Current Organism:
Thermococcus cleftensis
NCBI taxonomy Id: 163003
Other names: DSM 27260, KACC 17922, T. cleftensis, Thermococcus cleftensis Hensley et al. 2014, Thermococcus sp. CL1, strain CL1
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