STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CL1_1305iron(III)-siderophore ABC transporter ATPase 2; COG1120. (239 aa)    
Predicted Functional Partners:
CL1_1306
iron(III)-siderophore ABC transporter permease 2; COG0609.
 
 
 0.992
CL1_1240
iron(III)-siderophore ABC transporter permease 1; COG0609.
 
 
 0.923
psmB-2
Proteasome subunit beta 2; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
       0.867
CL1_0137
Iron (III) ABC transporter periplasmic-binding protein; COG0614.
 
 
 0.846
CL1_1302
Threonine synthase 2; COG0498.
       0.807
CL1_1303
Hypothetical protein.
       0.785
CL1_1241
iron(III)-siderophore ABC transporter ATP-binding protein; COG0614.
 
 
 0.774
CL1_1309
Hypothetical protein containing acyl-CoA N-acyltransferases (Nat)-domain; COG0456.
  
    0.703
endA
tRNA-splicing endonuclease subunit alpha; Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.
       0.698
mre11
DNA double-strand break repair protein mre11; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family.
     
 0.663
Your Current Organism:
Thermococcus cleftensis
NCBI taxonomy Id: 163003
Other names: DSM 27260, KACC 17922, T. cleftensis, Thermococcus cleftensis Hensley et al. 2014, Thermococcus sp. CL1, strain CL1
Server load: low (36%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.