STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
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Coexpression
Experiments
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[Homology]
Score
CL1_1355Nicotinate phosphoribosyltransferase; COG1488. (390 aa)    
Predicted Functional Partners:
CL1_0684
Pyrazinamidase/nicotinamidase-like protein; COG1335.
 
 0.978
CL1_0797
Nicotinate-nucleotide pyrophosphorylase; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family.
   
 0.967
CL1_1539
Archaeal nicotinamide-nucleotide adenylyltransferase; COG1056.
    
 0.943
surE
Putative stationary phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
    
 0.906
nadE
Putative NAD synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.
 
  
 0.685
CL1_1356
Short-chain alcohol dehydrogenase; COG1028.
   
 
 0.661
CL1_1357
Hypothetical protein; COG2248; Belongs to the UPF0282 family.
 
     0.591
CL1_1997
Hypothetical protein containing isochorismatase domain; COG1535.
 
  
 0.533
nadK
NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
 
  
 0.514
CL1_0748
Glycosyl transferase family 2 protein 2; COG0463.
  
  
 0.479
Your Current Organism:
Thermococcus cleftensis
NCBI taxonomy Id: 163003
Other names: DSM 27260, KACC 17922, T. cleftensis, Thermococcus cleftensis Hensley et al. 2014, Thermococcus sp. CL1, strain CL1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.