Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
CL1_1356Short-chain alcohol dehydrogenase; COG1028. (267 aa)    
Predicted Functional Partners:
secY
Preprotein translocase subunit SecY; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.
 
  
 
 0.710
CL1_1404
acetyl-CoA acetyltransferase; COG0183.
 
 
 0.686
CL1_1355
Nicotinate phosphoribosyltransferase; COG1488.
   
 
 0.661
CL1_1601
Asparagine synthase; COG0367.
 
 
 
 0.656
mre11
DNA double-strand break repair protein mre11; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family.
  
 
 0.651
CL1_0598
Hypothetical protein; COG0300.
 
 
 0.627
CL1_1898
Amino acid transporter; COG0531.
 
 
 0.613
CL1_1720
Putative Serine/threonine protein phosphatase; COG0631.
  
 
 0.559
CL1_0638
Glutamate synthase beta chain-related oxidoreductase containing 2Fe-2S and 4Fe-4S clusters; COG0493.
     
 0.544
CL1_0201
NADH dehydrogenase subunit D; COG0649; Belongs to the complex I 49 kDa subunit family.
 
 
 0.516
Your Current Organism:
Thermococcus cleftensis
NCBI taxonomy Id: 163003
Other names: DSM 27260, KACC 17922, T. cleftensis, Thermococcus cleftensis Hensley et al. 2014, Thermococcus sp. CL1, strain CL1
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