STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CL1_1357Hypothetical protein; COG2248; Belongs to the UPF0282 family. (300 aa)    
Predicted Functional Partners:
CL1_1358
Hypothetical protein.
       0.597
nep1
Ribosome biogenesis protein; Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA.
 
     0.576
CL1_0159
Putative RNA-binding protein containing THUMP domain; COG1818.
  
     0.572
rpl18a
50S ribosomal protein LX; COG2157.
  
   
 0.510
CL1_1496
Hypothetical protein; COG2090.
  
   
 0.503
CL1_1595
Nucleotidyltransferase; COG2413.
  
     0.498
rpl14e
50S ribosomal protein L14e; COG2163; Belongs to the eukaryotic ribosomal protein eL14 family.
  
     0.435
rgy
Reverse gyrase; Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication; In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.
  
     0.434
CL1_0719
Hypothetical protein; COG1341.
  
     0.432
CL1_0223
Putative TBP-interacting protein DNA helicase Tip49-like protein; COG1224.
  
     0.431
Your Current Organism:
Thermococcus cleftensis
NCBI taxonomy Id: 163003
Other names: DSM 27260, KACC 17922, T. cleftensis, Thermococcus cleftensis Hensley et al. 2014, Thermococcus sp. CL1, strain CL1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.