| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CL1_0735 | CL1_0953 | CL1_0735 | CL1_0953 | Diphthamide synthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Histone acetyltransferase-like protein; COG1243. | 0.497 |
| CL1_0735 | CL1_1476 | CL1_0735 | CL1_1476 | Diphthamide synthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Hypothetical protein; COG2102. | 0.675 |
| CL1_0735 | dphB | CL1_0735 | CL1_1363 | Diphthamide synthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.912 |
| CL1_0735 | eif2b | CL1_0735 | CL1_0653 | Diphthamide synthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Translation initiation factor IF-2 subunit beta; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-beta/eIF-5 family. | 0.600 |
| CL1_0735 | eif6 | CL1_0735 | CL1_1574 | Diphthamide synthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Translation initiation factor IF-6; Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex. | 0.470 |
| CL1_0735 | fusA | CL1_0735 | CL1_1929 | Diphthamide synthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Elongation factor EF-2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. | 0.973 |
| CL1_0735 | prf1 | CL1_0735 | CL1_0178 | Diphthamide synthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | Putative peptide chain release factor 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. | 0.410 |
| CL1_0735 | rps4e | CL1_0735 | CL1_0615 | Diphthamide synthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | 30S ribosomal protein S4e; COG1471; Belongs to the eukaryotic ribosomal protein eS4 family. | 0.576 |
| CL1_0953 | CL1_0735 | CL1_0953 | CL1_0735 | Histone acetyltransferase-like protein; COG1243. | Diphthamide synthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | 0.497 |
| CL1_0953 | CL1_2028 | CL1_0953 | CL1_2028 | Histone acetyltransferase-like protein; COG1243. | Hypothetical protein; COG2520. | 0.441 |
| CL1_0953 | dphB | CL1_0953 | CL1_1363 | Histone acetyltransferase-like protein; COG1243. | Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.540 |
| CL1_0953 | eif6 | CL1_0953 | CL1_1574 | Histone acetyltransferase-like protein; COG1243. | Translation initiation factor IF-6; Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex. | 0.419 |
| CL1_0953 | prf1 | CL1_0953 | CL1_0178 | Histone acetyltransferase-like protein; COG1243. | Putative peptide chain release factor 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. | 0.487 |
| CL1_1476 | CL1_0735 | CL1_1476 | CL1_0735 | Hypothetical protein; COG2102. | Diphthamide synthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family. | 0.675 |
| CL1_1476 | dphB | CL1_1476 | CL1_1363 | Hypothetical protein; COG2102. | Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.751 |
| CL1_1476 | eif2b | CL1_1476 | CL1_0653 | Hypothetical protein; COG2102. | Translation initiation factor IF-2 subunit beta; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-beta/eIF-5 family. | 0.475 |
| CL1_1476 | fusA | CL1_1476 | CL1_1929 | Hypothetical protein; COG2102. | Elongation factor EF-2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. | 0.999 |
| CL1_1476 | rps4e | CL1_1476 | CL1_0615 | Hypothetical protein; COG2102. | 30S ribosomal protein S4e; COG1471; Belongs to the eukaryotic ribosomal protein eS4 family. | 0.425 |
| CL1_2028 | CL1_0953 | CL1_2028 | CL1_0953 | Hypothetical protein; COG2520. | Histone acetyltransferase-like protein; COG1243. | 0.441 |
| CL1_2028 | dphB | CL1_2028 | CL1_1363 | Hypothetical protein; COG2520. | Diphthine synthase; S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. | 0.600 |