STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
smcChromosome segregation protein SMC; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1188 aa)    
Predicted Functional Partners:
CL1_1614
Chromosome segregation and condensation protein ScpA-like protein; COG1354.
 
 
 0.989
CL1_0713
Segregation and condensation protein B; COG1386.
 
 
 0.749
topA
DNA topoisomerase, type IA; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing D [...]
 
 
 0.614
CL1_1616
Hef nuclease; COG1111.
 
 
 0.604
CL1_1612
Hypothetical protein.
       0.603
CL1_1412
Putative histone deacetylase; COG0123.
 
 
 0.590
CL1_1611
methylmalonyl-CoA epimerase; COG0346.
  
    0.538
CL1_1610
Lysine/arginine/ornithine transport system kinase; COG1703.
       0.530
CL1_1649
Putative Rad3-related DNA helicase; COG1199.
 
 
 0.485
CL1_1608
Hypothetical protein containing PHP domain; COG1387.
 
 
   0.448
Your Current Organism:
Thermococcus cleftensis
NCBI taxonomy Id: 163003
Other names: DSM 27260, KACC 17922, T. cleftensis, Thermococcus cleftensis Hensley et al. 2014, Thermococcus sp. CL1, strain CL1
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