CL1_1616 protein (Thermococcus cleftensis) - STRING interaction network

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Score

CL1_1616

Hef nuclease; COG1111. (785 aa)

Predicted Functional Partners:

CL1_0714

0.874

rpl1

0.855

CL1_1615

0.822

CL1_0698

0.722

rpl40e

0.707

topA

0.654

CL1_1720

0.654

pcn

0.654

CL1_1633

0.639

fen

0.628

Your Current Organism:

Thermococcus cleftensis

NCBI taxonomy Id: 163003
Other names: DSM 27260, KACC 17922, T. cleftensis, Thermococcus cleftensis Hensley et al. 2014, Thermococcus sp. CL1, strain CL1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CL1_0698	CL1_0714	CL1_0698	CL1_0714	DNA polymerase, family B; COG0417.	Replication factor A; COG1599.	0.833
CL1_0698	CL1_1616	CL1_0698	CL1_1616	DNA polymerase, family B; COG0417.	Hef nuclease; COG1111.	0.722
CL1_0698	CL1_1633	CL1_0698	CL1_1633	DNA polymerase, family B; COG0417.	Putative DNA glycosylase; COG0122.	0.531
CL1_0698	CL1_1720	CL1_0698	CL1_1720	DNA polymerase, family B; COG0417.	Putative Serine/threonine protein phosphatase; COG0631.	0.519
CL1_0698	fen	CL1_0698	CL1_1585	DNA polymerase, family B; COG0417.	Flap endonuclease-1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...]	0.981
CL1_0698	pcn	CL1_0698	CL1_1865	DNA polymerase, family B; COG0417.	DNA polymerase sliding clamp protein; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.	0.998
CL1_0698	rpl40e	CL1_0698	CL1_0585	DNA polymerase, family B; COG0417.	50S ribosomal protein L40e; COG1552; Belongs to the eukaryotic ribosomal protein eL40 family.	0.769
CL1_0698	topA	CL1_0698	CL1_0389	DNA polymerase, family B; COG0417.	DNA topoisomerase, type IA; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing D [...]	0.662
CL1_0714	CL1_0698	CL1_0714	CL1_0698	Replication factor A; COG1599.	DNA polymerase, family B; COG0417.	0.833
CL1_0714	CL1_1616	CL1_0714	CL1_1616	Replication factor A; COG1599.	Hef nuclease; COG1111.	0.874
CL1_0714	CL1_1720	CL1_0714	CL1_1720	Replication factor A; COG1599.	Putative Serine/threonine protein phosphatase; COG0631.	0.647
CL1_0714	fen	CL1_0714	CL1_1585	Replication factor A; COG1599.	Flap endonuclease-1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...]	0.737
CL1_0714	pcn	CL1_0714	CL1_1865	Replication factor A; COG1599.	DNA polymerase sliding clamp protein; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.	0.959
CL1_0714	topA	CL1_0714	CL1_0389	Replication factor A; COG1599.	DNA topoisomerase, type IA; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing D [...]	0.759
CL1_1615	CL1_1616	CL1_1615	CL1_1616	Hypothetical protein.	Hef nuclease; COG1111.	0.822
CL1_1616	CL1_0698	CL1_1616	CL1_0698	Hef nuclease; COG1111.	DNA polymerase, family B; COG0417.	0.722
CL1_1616	CL1_0714	CL1_1616	CL1_0714	Hef nuclease; COG1111.	Replication factor A; COG1599.	0.874
CL1_1616	CL1_1615	CL1_1616	CL1_1615	Hef nuclease; COG1111.	Hypothetical protein.	0.822
CL1_1616	CL1_1633	CL1_1616	CL1_1633	Hef nuclease; COG1111.	Putative DNA glycosylase; COG0122.	0.639
CL1_1616	CL1_1720	CL1_1616	CL1_1720	Hef nuclease; COG1111.	Putative Serine/threonine protein phosphatase; COG0631.	0.654