STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
thiIThiamine biosynthesis protein; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (380 aa)    
Predicted Functional Partners:
CL1_1663
Hypothetical protein; COG0301.
 
  
 
0.961
CL1_1660
Hypothetical protein; COG2177.
       0.818
CL1_1662
Hypothetical protein; COG3371.
       0.805
CL1_1659
Hypothetical protein; COG0778.
       0.668
CL1_0035
Putative phosphomethylpyrimidine kinase; COG1992.
     
 0.591
CL1_1658
Putative maleate cis-trans isomerase; COG3473.
       0.567
CL1_0256
Hypothetical protein; COG0144; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
  
    0.474
CL1_0700
Hypothetical protein containing sun-domain; COG0144; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
  
    0.473
CL1_0732
Hypothetical protein containing fmu domain; COG0144; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
  
    0.473
CL1_1092
Nol1-nop2-sun family nucleolar protein III; COG0144; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.
  
    0.473
Your Current Organism:
Thermococcus cleftensis
NCBI taxonomy Id: 163003
Other names: DSM 27260, KACC 17922, T. cleftensis, Thermococcus cleftensis Hensley et al. 2014, Thermococcus sp. CL1, strain CL1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.