STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
CL1_1807Biotin-protein ligase; COG0340. (237 aa)    
Predicted Functional Partners:
CL1_0654
methylmalonyl-CoA decarboxylase subunit alpha; COG4799.
 
 
 0.892
CL1_1808
Proton/glutamate symporter; COG1301.
     
 0.892
CL1_1806
Fructose 1,6-bisphosphate aldolase; COG1830.
       0.838
CL1_1805
Pyruvate carboxylase subunit B; COG5016.
 
     0.833
CL1_1697
Putative biotin biosynthesis protein BioY; COG1268.
 
   
 0.741
rnj
Hypothetical protein containing metallo-beta-lactamase superfamily; An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation; Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lactamase-like family. Archaeal RNase J subfamily.
      0.644
CL1_1810
Hypothetical protein containing alanyl tRNA synthase domain; COG2872.
 
  
 0.637
CL1_0656
Putative methylmalonyl-CoA decarboxylase subunit gamma; COG0511.
 
   
 0.635
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
     
 0.630
tpiA
Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family.
  
  
 0.566
Your Current Organism:
Thermococcus cleftensis
NCBI taxonomy Id: 163003
Other names: DSM 27260, KACC 17922, T. cleftensis, Thermococcus cleftensis Hensley et al. 2014, Thermococcus sp. CL1, strain CL1
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