Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
CL1_1816CRISPR-associated autoregulator, DevR family 2; COG1857. (327 aa)    
Predicted Functional Partners:
CL1_1815
CRISPR-associated protein Cas5; COG1688.
 
 
 0.984
CL1_1817
Hypothetical protein.
       0.901
CL1_0378
CRISPR-associated protein Cas5, Tneap type; COG1688.
 
 
 0.879
CL1_1818
CRISPR-associated Cas6 family protein 2; COG1583.
 
   
 0.839
CL1_0379
CRISPR-associated helicase Cas3; COG1203.
 
 
 0.786
CL1_1811
CRISPR-associated helicase Cas3 domain-containing protein; COG1203.
 
 
 0.765
CL1_0376
CRISPR-associated CXXC_CXXC protein Cst1.
 
     0.720
CL1_0507
Glycosyl transferase family protein 6; COG1807.
  
     0.549
CL1_1812
CRISPR-associated Cas4 family protein 3; CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Belongs to the CRISPR-associated exonuclease Cas4 family.
 
   
 0.525
cas1
CRISPR-associated protein Cas1, HMARI/TNEAP subtype; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
 
   
 0.506
Your Current Organism:
Thermococcus cleftensis
NCBI taxonomy Id: 163003
Other names: DSM 27260, KACC 17922, T. cleftensis, Thermococcus cleftensis Hensley et al. 2014, Thermococcus sp. CL1, strain CL1
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